Multi-level Regression#

[1]:
import arviz as az
import bambi as bmb
import numpy as np
import matplotlib.pyplot as plt
import statsmodels.api as sm
[2]:
az.style.use('arviz-darkgrid')
np.random.seed(12345)
In this notebook we demo how to perform a Bayesian multi-level regression.
We’ll use a multi-level dataset included with statsmodels containing the growth curve of pigs. Since the weight of each pig is measured multiple times, we’ll estimate a model that allows varying intercepts and slopes for time, for each pig.

Load data#

[3]:
# Load up data from statsmodels
data = sm.datasets.get_rdataset('dietox', 'geepack').data
data.describe()
[3]:
Pig Litter Start Weight Feed Time
count 861.000000 861.000000 861.000000 861.000000 789.000000 861.000000
mean 6238.319396 12.135889 25.672701 60.725769 80.728645 6.480836
std 1323.845928 7.427252 3.624336 24.978881 52.877736 3.444735
min 4601.000000 1.000000 15.000000 15.000000 3.300003 1.000000
25% 4857.000000 5.000000 23.799990 38.299990 32.800003 3.000000
50% 5866.000000 11.000000 25.700000 59.199980 74.499996 6.000000
75% 8050.000000 20.000000 27.299990 81.199950 123.000000 9.000000
max 8442.000000 24.000000 35.399990 117.000000 224.500000 12.000000

Model#

\[Y_i = \beta_{0, i} + \beta_{1, i} X + \epsilon_i\]

with

\(\beta_{0, i} = \beta_0 + \alpha_{0, i}\)
\(\beta_{1, i} = \beta_1 + \alpha_{1, i}\)

where \(\beta_0\) and \(\beta_1\) are usual common intercept and slope you find in a linear regression. \(\alpha_{0, i}\) and \(\alpha_{1, i}\) are the group specific components for the pig \(i\), influencing the intercept and the slope respectively. Finally \(\epsilon_i\) is the random error we always see in this type of models, assumed to be Gaussian with mean 0. Note that here we use “common” and “group specific” effects to denote what in many fields are known as “fixed” and “random” effects, respectively.

We use the formula syntax to specify the model. Previously, you had to specify common and group specific components separately. Now, thanks to formulae, you can specify model formulas just as you would do with R packages like lme4 and brms. In a nutshell, the term on the left side tells Weight is the response variable, Time on the right-hand side tells we include a main effect for the variable Time, and (Time|Pig) indicates we want to allow a each pig to have its own slope for Time as well as its own intercept (which is implicit). If we only wanted different intercepts, we would have written Weight ~ Time + (1 | Pig) and if we wanted slopes specific to each pig without including a pig specific intercept, we would write Weight ~ Time + (0 + Time | Pig).

[4]:
model = bmb.Model(data)
results = model.fit("Weight ~ Time + (Time|Pig)")
Auto-assigning NUTS sampler...
Initializing NUTS using jitter+adapt_diag...
Multiprocess sampling (2 chains in 2 jobs)
NUTS: [Weight_sigma, Time|Pig_offset, Time|Pig_sigma, 1|Pig_offset, 1|Pig_sigma, Time, Intercept]
100.00% [4000/4000 00:23<00:00 Sampling 2 chains, 0 divergences]
Sampling 2 chains for 1_000 tune and 1_000 draw iterations (2_000 + 2_000 draws total) took 25 seconds.
The number of effective samples is smaller than 25% for some parameters.

Random intercept#

Since we have not specified prior distributions for the parameters in the model, Bambi has chosen sensible defaults for us. We can explore these priors through samples generated from them with a call to Model.plot_priors(), which plots a kernel density estimate for each prior.

[5]:
model.plot_priors();
../_images/notebooks_multi-level_regression_10_0.png

Now we are ready to check the results. Using az.plot_trace() we get traceplots that show the values sampled from the posteriors and density estimates that gives us an idea of the shape of the posterior distribution of our parameters.

In this case it is very convenient to use compact=True. We tell ArviZ to plot all the group specific posteriors in the same panel which saves space and makes it easier to compare group specific posteriors. Thus, we’ll have a panel with all the group specific intercepts, and another panel with all the group specific slopes. If we used compact=False, which is the default, we would end up with a huge number of panels which would make the plot unreadable.

[6]:
# Plot posteriors
az.plot_trace(
    results,
    var_names=['Intercept', 'Time', '1|Pig', 'Time|Pig', 'Weight_sigma'],
    compact=True
);
../_images/notebooks_multi-level_regression_12_0.png

The same plot could have been generated with less typing by calling

az.plot_trace(results, var_names=["~1|Pig_sigma", "~Time|Pig_sigma"], compact=True);

which uses an alternative notation to pass var_names based on the negation symbol in Python, ~. There we are telling ArviZ to plot all the variables in the InferenceData object results, except from 1|Pig_sigma and Time|Pig_sigma.
Can’t believe it? Come on, run this notebook on your side and have a try!

The plots generated by az.plot_trace() are enough to be confident that the sampler did a good job and conclude about plausible values for the distribution of each parameter in the model. But if we want to, and it is a good idea to do it, we can get umerical summaries for the posteriors with az.summary().

[7]:
az.summary(results, var_names=['Intercept', 'Time', '1|Pig_sigma', 'Time|Pig_sigma', 'Weight_sigma'])
[7]:
mean sd hdi_3% hdi_97% mcse_mean mcse_sd ess_bulk ess_tail r_hat
Intercept 15.774 0.579 14.666 16.867 0.030 0.021 370.0 828.0 1.00
Time 6.932 0.084 6.784 7.095 0.005 0.003 331.0 498.0 1.01
1|Pig_sigma 4.537 0.425 3.804 5.381 0.017 0.012 611.0 953.0 1.01
Time|Pig_sigma 0.662 0.059 0.557 0.778 0.003 0.002 558.0 823.0 1.00
Weight_sigma 2.460 0.067 2.334 2.584 0.001 0.001 2194.0 1626.0 1.00

Estimated regression line#

Here we’ll visualize the regression equations we have sampled for a particular pig and then we’ll compare the mean regression equation for all the 72 pigs in the dataset.

In the following plot we can see the 2000 linear regressions we have sampled for the pig ‘4601’. The mean regression line is plotted in black and the observed weights for this pig are respresented by the blue dots.

[8]:
# The ID of the first pig is '4601'
data_0 = data[data['Pig'] == 4601][['Time', 'Weight']]
time = np.array([1, 12])

intercept_common = results.posterior['Intercept'].stack(draws=("chain", "draw"))
slope_common = results.posterior['Time'].stack(draws=("chain", "draw"))

intercept_specific_0 = results.posterior['1|Pig'].stack(draws=("chain", "draw"))[0]
slope_specific_0 = results.posterior['Time|Pig'].stack(draws=("chain", "draw"))[0]

a = (intercept_common + intercept_specific_0).values
b = (slope_common + slope_specific_0).values

plt.plot(time, a + b * time[:,None], color="C1", lw=0.1, zorder=1)
plt.plot(time, a.mean() + b.mean() * time, color="black", zorder=1)
plt.scatter(data_0['Time'], data_0['Weight'], zorder=2)
plt.ylabel('Weight (kg)')
plt.xlabel('Time (weeks)');
../_images/notebooks_multi-level_regression_17_0.png

Next, we calculate the mean regression line for each pig and show them together in one plot. Here we clearly see each pig has a different pair of intercept and slope.

[9]:
intercept_group_specific = results.posterior['1|Pig'].stack(draws=("chain", "draw"))
slope_group_specific = results.posterior['Time|Pig'].stack(draws=("chain", "draw"))
a = (intercept_common.mean() + intercept_group_specific.mean(axis=1)).values
b = (slope_common.mean() + slope_group_specific.mean(axis=1)).values
plt.plot(time, a + b * time[:,None], color="C1", alpha=0.7, lw=0.8)
plt.ylabel('Weight (kg)')
plt.xlabel('Time (weeks)');
../_images/notebooks_multi-level_regression_19_0.png

We can get credible interval plots with ArviZ. Here the line indicates a 94% credible interval calculated as higher posterior density, the thicker line represents the interquartile range and the dot is the median. We can quickly note two things:

  • The uncertainty about the intercept estimate is much higher than the uncertainty about the Time slope.

  • The credible interval for Time is far away from 0, so we can be confident there’s a positive relationship the Weight of the pigs and Time.

We’re not making any great discovering by stating that as time passes we expect the pigs to weight more, but this very simple example can be used as a starting point in applications where the relationship between the variables is not that clear beforehand.

[10]:
az.plot_forest(
    results,
    var_names=['Intercept', 'Time'],
    figsize=(8, 2),
);
../_images/notebooks_multi-level_regression_21_0.png

We can also plot the posterior overlayed with a region of practical equivalence (ROPE). This region indicates a range of parameter values that are considered to be practically equivalent to some reference value of interest to the particular application, for example 0. In the following plot we can see that all our posterior distributions fall outside of this range.

[11]:
az.plot_posterior(
    results,
    var_names=['Intercept', 'Time'],
    ref_val=0,
    rope=[-1, 1]
);
../_images/notebooks_multi-level_regression_23_0.png
[12]:
%load_ext watermark
%watermark -n -u -v -iv -w
Last updated: Mon Feb 22 2021

Python implementation: CPython
Python version       : 3.8.5
IPython version      : 7.18.1

arviz      : 0.11.2
statsmodels: 0.12.2
bambi      : 0.3.0
matplotlib : 3.3.3
numpy      : 1.20.1

Watermark: 2.1.0